Proven Efficacy
"Silicone gel dispensed from a tube has significant benefits in ease of use, but different formulations of silicone gel may vary in efficacy." [1]

Studies on the Efficacy of Dermatix® in Scar Management
Study Patients Intervention Scar Evaluation Outcome
Controlled Comparative Study
Chan et al. [2]; prospective, randomized, double-masked, within-subkect comparison study 50 Asian patients who underwent median sternotomy Twice-daily silicone gel on half of wound compared with placebo gel on other half of wound from postoperative week 2 to month 3 Vancouver Scar Scale scores of pigmentaion, vascularity, pliability, height, pain, and itchiness Scars that developed during silicone gel treatment were significantly flatter, less red, and more pliable and associated with significantly less pain and itching than scars that developed during placebo treatment
Signorini and Clementoni [3]; prospoective, randomized, parallel-group comparison study 160 patients who underwent surgery Twice-daily silicone gel treatment compared with no treatment initiated from 10 days to 3 weeks after surgery for 4 months Scar quality (normal mature, slightly hypertrophic, hypertrophic, or keloid scar based on color, hardness, elevation, and relationship to wound margins) Scar quality was significantly better in the silicone gel group than in the no treatment group at the 6-month follow-up visit: the incidence of hypertrophic of keloid scarring was 7% in the silicone gel group compared with 26% in the no treatment group
Chernoff et al. [4]; prospoective, within-subject comparison study 30 patients with bilateral hypertrophic scars, keloids, or scars will in an erythematous and raised stage of healing Silicone gel, SGS, or a combination of treatments for one scar compared with no treatment for the bilateral scar for 3 months Scar elevation and skin surface texture measued using optical profilometryl erythema; pliability; severity of symptoms Scars treated with silicone gel, SGS, or silicone gel/SGS were statistically significantly less elevated, less red, and associated with fewer sympromes than untreated scars
Fonseca Capdevilla et al. [5]; prospective, parallel-group comparison study 132 patients who underwent removal of a benign skin lesion Silicone gel treatment compared with SGS treatments initiated within 1 monnth of surgey Height; redness; pliability; itching; pain/tenderness Silicone gel and SGS were both effective in improving scar redness, hardness, elevation, pain, and itching; there were no statistically significant differences between silicone and SGS on any efficay parameter at the month 6 follow-up
Large-scale Observational Study
Sepehrmanesh [6]; prospective, open-label, non-controlled study 1,522 patients with scars Silicone gel was aplpied on average twice daily for 2 to 6 months, maximum 10 months Height; color; pliability; itching; pain/tenderness Improvement in scar color, pliability, height, itching, and pain/tenderness after silicone gel treatment of approximately 70% to 84.2% of patients
Small Case Series
Murison and James [7]; prospective, noncontrolled study 6 patients with excessive scars (most at least 2 years old) Silicone gel used for 8 weeks Adapted Vancouver Scar Scale scores of elevation, redness, hardness, itching, tenderness and painl collagen content and blood flow measured using intracutaneous spectrophotometry All scars showed improvement in redness, elevation, hardness, and itching, and pain was reduced in symptomatic scars